GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs1061377 | 1 | rs10027813 | chr4:39121438 | KLHL5 | chr4:39046659-39123828:+ | -0.15 | -4.71 | 2.77E-6 | Uric acid levels |
| BRCA | cis | rs10029851 | 1 | rs10029851 | chr4:109628025 | LOC285456 | chr4:109459346-109541613:- | 0.25 | 5.25 | 1.82E-7 | Amyotrophic lateral sclerosis (sporadic) |
| BRCA | cis | rs11097912 | 1 | rs10030019 | chr4:106998448 | TBCK | chr4:106967233-107237861:- | 0.23 | 7.28 | 6.31E-13 | Airflow obstruction |
| BRCA | cis | rs1061377 | 1 | rs10030904 | chr4:39115223 | KLHL5 | chr4:39046659-39123828:+ | -0.16 | -5.01 | 6.29E-7 | Uric acid levels |
| BRCA | cis | rs4864809 | 1 | rs10031525 | chr4:54519579 | LNX1 | chr4:54326439-54518682:- | 0.13 | 3.45 | 0.000582 | Beard thickness |
| BRCA | cis | rs1008375 | 1 | rs10032326 | chr4:17630717 | MED28 | chr4:17616273-17629791:+ | 0.14 | 3.61 | 0.000325 | Parasitemia in Tripanosoma cruzi seropositivity |
| BRCA | cis | rs10043228 | 1 | rs10036292 | chr5:115595871 | COMMD10 | chr5:115420727-115628978:+ | 0.22 | 4.57 | 5.42E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10037055 | 1 | rs10037055 | chr5:176691279 | MXD3 | chr5:176732501-176739292:- | 0.11 | 4.77 | 2.08E-6 | Migraine without aura |
| BRCA | cis | rs1003719 | 1 | rs1003719 | chr21:38491095 | PIGP | chr21:38437664-38445458:- | -0.25 | -7.74 | 2.36E-14 | Eye color traits |
| BRCA | cis | rs6452524 | 1 | rs10037872 | chr5:82439920 | XRCC4 | chr5:82373317-82649577:+ | -0.12 | -3.57 | 0.000372 | Hypertension |
| BRCA | cis | rs7705819 | 1 | rs10041281 | chr5:172886305 | ATP6V0E1 | chr5:172410763-172461900:+ | -0.1 | -3.4 | 0.000702 | Stroke |
| BRCA | cis | rs6452524 | 1 | rs10042854 | chr5:82439695 | TMEM167A | chr5:82348667-82373272:- | 0.12 | 4.23 | 2.54E-5 | Hypertension |
| BRCA | cis | rs6452524 | 1 | rs10042854 | chr5:82439695 | XRCC4 | chr5:82373317-82649577:+ | 0.15 | 4.22 | 2.63E-5 | Hypertension |
| BRCA | cis | rs6452524 | 1 | rs10043018 | chr5:82434317 | XRCC4 | chr5:82373317-82649577:+ | -0.12 | -3.54 | 0.000411 | Hypertension |
| BRCA | cis | rs10043228 | 1 | rs10043228 | chr5:115597048 | COMMD10 | chr5:115420727-115628978:+ | 0.22 | 4.57 | 5.36E-6 | Asthma or chronic obstructive pulmonary disease |